Effect of Nigella Sativa L. seeds on ovaries function in adult Rats treated with Lead Acetate
Al- Anbar Medical Journal,
2011, Volume 9, Issue 1, Pages 59-70
AbstractBackground: There is an increasing interest toward medicinal plants and their active ingredients in the last years. Aims of the Study: This study aimed to show the effect of Nagela sativa L. seeds on the functions of ovaries in adult rats treated with lead acetate.Materials and Methods : Thirty adult female rats were randomly divided into three groups and treated orally as following for 8 weeks . Rats in the first group were received one ml of distilled water as control group . Rats in the second group were received lead acetate ( 10 mg / kg ) as test 1 group. While rats in the third group received 100 mg/kg seeds of Nigella sativa with 10 mg /kg lead acetate as test group-2. Fasting blood specimens were collected to poll serum 2,4,and 8 weeks for the measurement of LH, FSHAnd estrogen hormone.Results: The results revealed significant (P<0.05) increase in ovarian weight to body weight ratio, FSH, numbers and diameters of graffian follicles in two treated groups (T1andT2)compared with control group. Exposure of animals to lead acetate (T1) reflects a significant (P<0.05) increase in LH hormones with a significant decrease in estrogen compared with control group. Treatment of animals with Nigella Sativa pulse lead acetate caused significant (P<0.05) decrease in serum LH hormone compared with T1 group but the concentration of estrogen was significantly (P<0.05) increase.Ovaries histological studies of (T1 group) indicated an increase in diameters of graffian follicles and vaculation of granulosa cells, while the ovary of the animals in (T2 group) showed decrease in number and diameter of graffian follicles in comparison with normal structure of these follicles. On conclusion it seems likely that dosage of rats with (10 mg/kg B.W) of lead acetate caused a significant redaction on ovarian function and the treatment of animals with (100 mg/kg B.W) of Nigella sativa caused a significant enhancement of its reproductive function.Keywords : Nigella sativa , ovarian hormones, lead acetate, medicinal plants.
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