Al- Anbar Medical Journal

Does Rheumatoid Factor have any Protective Role in Patients with Lupus Nephritis

Document Type : Original articles

Authors

1 Rheumatology Department, Al-Ramadi Teaching Hospital, Anbar Health Directorate, Ramadi, Anbar, Iraq.

2 Rheumatology Department, College of Medicine, University of Baghdad, Baghdad, Iraq.

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that appears to result from an immune-regulatory disturbance caused by an interplay of genetic, hormonal, immunological, and environmental factors.
Objective: To test the hypothesis that rheumatoid factor (RF) protects against lupus nephritis in Iraqi patients with SLE.
Materials and Methods: Fifty-eight consecutive patients with SLE, who fulfilled the American College of Rheumatology (ACR) revised criteria for the diagnosis of SLE and attend the rheumatology unit of Baghdad Teaching Hospital during the period June 2000 to June 2001 were enrolled in the study. SLE patients divided into 2 groups (with lupus nephritis=30, without lupus nephritis =28) and a third group of control patients =30.
Results: All SLE patients with and without lupus nephritis had positive antinuclear antibodies. There were no obvious differences in the positivity rate of RF in SLE patients both with and without lupus nephritis (P-Value > 0.05). The disease activity was slightly higher in those with RF positives compared to those with RF negatives. The disease activity score was significantly higher in those with lupus nephritis compared to those with no lupus nephritis (p=0.007)
Conclusions: RF appears to play no significant role in the protection of renal disease in Iraqi patients with SLE. The presence of RF in SLE patients is associated with a lower disease activity score. The presence of lupusnephritis is associated with a higher disease activity score.

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References
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Al- Anbar Medical Journal
Volume 16, Issue 2
December 2020
Page 40-45
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