Al- Anbar Medical Journal

The Significance of Blood Eosinophilia in Atopic Dermatitis

Document Type : Original articles

Authors

Department of Dermatology, Hit General Hospital, Anbar Health Directorate, Anbar, Iraq.

Abstract

Background: Atopic dermatitis (AD) is chronic relapsing, pruritic, inflammatory skin disease. Itusually accompanies other atopic problems like asthma and allergic rhinitis. Eosinophil plays a rolein patients with AD.Objectives: To assess blood eosinophils in patients with AD and to evaluate the factors that areaffecting the blood eosinophilia.Materials and methods: This prospective study was conducted at Hit General Hospital in theperiod from October 2018-October 2019. The age, gender, and personal or family history of asthmaor allergic rhinitis of the patients with AD were recorded. The severity of the disease was assessedby the SCORAD score. The total number of eosinophil was measured for each subject. The datawere analyzed using SPSS version 22.Results: Out of 70 patients with AD, 38 (54.3%) were females, and 32 (45.7%) males. The age ofthe patients ranged from 8 months to 30 years (mean 7.59±7.40). The highest age group affectedwas 2-12 years 40 (57.1%). The SCORAD score ranged from 6-80 (mean 24.19±17.59). Themajority of our patients with mild course 50 (71.1%). The majority of the cases were without ahistory of asthma (n=53,75.7%), and around 50% without allergic rhinitis. The range of eosinophilcount was 42-3360 (mean 636.44±491.37). The majority of the subjects (n=53,75.7%) with mildeosinophilia (500-1500/ mm3). The age, gender, and patients with a history of allergic rhinitis orasthma had no significant effect on the number of eosinophils (P-Value >0.05). While, there wasa high statistically significant difference between the eosinophils count, and the severity of AD(P-Value=0.000).Conclusion: From these findings we concluded that blood eosinophilia is a relatively commonlaboratory finding of AD. Blood eosinophilia was influenced by the severity of AD.

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Main Subjects

References
[1]       J. D. Bernhard, “Clinical dermatology.: John Hunter, John Savin, and Mark Dahl, Vermont, 2003, Blackwell Publisher Co. 365 pages. $54.95. ISBN: 0-632-03714-8,” J. Am. Acad. Dermatol., vol. 50, no. 4, pp. 655–656, 2004.
[2]       H. C. Williams, “Atopic dermatitis,” N. Engl. J. Med., vol. 352, no. 22, pp. 2314–2324, 2005.
[3]       W. D. James, D. Elston, and T. Berger, Andrew’s Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences, 2011.
[4]       D. Simon, L. R. Braathen, and H. Simon, “Eosinophils and atopic dermatitis,” Allergy, vol. 59, no. 6, pp. 561–570, 2004.
[5]       M. K. Kumar, P. K. Singh, and P. K. Patel, “Clinico-immunological profile and their correlation with severity of atopic dermatitis in Eastern Indian children,” J. Nat. Sci. Biol. Med., vol. 5, no. 1, p. 95, 2014.
[6]       J. D. Peterson and L. S. Chan, “A comprehensive management guide for atopic dermatitis,” Dermatology Nurs., vol. 18, no. 6, p. 531, 2006.
[7]       R. Posnick, “Thomas P. Habif. Clinical Dermatology: A color Guide to Diagnosis and Therapy. St. Louis: Mosby; 904 pp, $149.00.” Elsevier, 2005.
[8]       J. M. Hanifin, “Diagnostic features of atopic dermatitis,” Acta Derm Venereol, vol. 92, pp. 44–47, 1980.
[9]       B. Dibbert et al., “Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5,” Blood, J. Am. Soc. Hematol., vol. 92, no. 3, pp. 778–783, 1998.
[10]     S. Dhar, R. Malakar, S. Chattopadhyay, S. Dhar, R. Banerjee, and A. Ghosh, “Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels,” Indian J. Dermatology, Venereol. Leprol., vol. 71, no. 4, p. 246, 2005.
[11]     A. S. Vekaria et al., “Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with skin disease activity,” F1000Research, vol. 6, 2017.
[12]     M. A. Bonilla and J. S. Menell, “Disorders of white blood cells,” in Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Elsevier, 2016, pp. 209–238.
[13]     J. F. Stalder et al., “Severity scoring of atopic dermatitis: the SCORAD index: consensus report of the european task force on atopic dermatitis,” Dermatology, vol. 186, no. 1, pp. 23–31, 1993.
[14]     T. Torres, E. Ferreira, M. Gonçalo, P. Mendes-Bastos, M. Selores, and P. Filipe, “Update on atopic dermatitis,” Acta Med. Port., vol. 32, no. 9, pp. 606–613, 2019.
[15]     T. Torres, “Atopic dermatitis: the new therapeutic revolution in dermatology,” Acta Med. Port., vol. 30, no. 10, pp. 669–670, 2017.
[16]     T. Bieber, “How to define atopic dermatitis?,” Dermatol. Clin., vol. 35, no. 3, pp. 275–281, 2017.
[17]     E. C. Milam, S. E. Jacob, and D. E. Cohen, “Contact dermatitis in the patient with atopic dermatitis,” J. Allergy Clin. Immunol. Pract., vol. 7, no. 1, pp. 18–26, 2019.
[18]     A. Paller et al., “Major comorbidities of atopic dermatitis: beyond allergic disorders,” Am. J. Clin. Dermatol., vol. 19, no. 6, pp. 821–838, 2018.
[19]     S. Nutten, “Atopic dermatitis: global epidemiology and risk factors,” Ann. Nutr. Metab., vol. 66, no. Suppl. 1, pp. 8–16, 2015.
[20]     H. C. Williams, Atopic dermatitis: the epidemiology, causes and prevention of atopic eczema. Cambridge University Press, 2000.
[21]     Y.-K. Tay, B.-P. Khoo, and C.-L. Goh, “The epidemiology of atopic dermatitis at a tertiary referral skin center in Singapore,” Asian Pacific J. allergy Immunol., vol. 17, no. 3, p. 137, 1999.
[22]     J. Celakovska et al., “Evaluation of peripheral blood eosinophilia in adolescent and adult patients suffering from atopic dermatitis and the relation to the occurrence of allergy to aeroallergens,” Indian J. Dermatol., vol. 64, no. 1, p. 34, 2019.
[23]     R. Luoma, A. Koivikko, and M. Viander, “Development of asthma, allergic rhinitis and atopic dermatitis by the age of five years: a prospective study of 543 newborns,” Allergy, vol. 38, no. 5, pp. 339–346, 1983.
[24]     F.-T. Liu, H. Goodarzi, and H.-Y. Chen, “IgE, mast cells, and eosinophils in atopic dermatitis,” Clin. Rev. Allergy Immunol., vol. 41, no. 3, pp. 298–310, 2011.
[25]     M. Uehara, R. Izukura, and T. Sawai, “Blood eosinophilia in atopic dermatitis,” Clin. Exp. Dermatol., vol. 15, no. 4, pp. 264–266, 1990.
[26]     D. Jenerowicz, M. Czarnecka-Operacz, and W. Silny, “Peripheral blood eosinophilia in atopic dermatitis,” ACTA DERMATOVENEROLOGICA Alp. Panon. Adriat., vol. 16, no. 2, p. 47, 2007.
 
Al- Anbar Medical Journal
Volume 17, Issue 1
June 2021
Page 16-19
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