Correlation of Testicular Volume and Semen Parameter with Varicocele Grades in Mosul City: A Case-Control Study
Al- Anbar Medical Journal,
2021, Volume 17, Issue 2, Pages 59-63
AbstractBackground: Varicocele is a status of abnormal dilatation and sinuosity of the pampiniformplexus that leading to a decrease in the volume of the impacted testicle. Approximately 15-20%and 35% of healthy adult males and men with primary infertility are affected respectively. It wasconsidered as one of the surgically correctible causes of male infertility.Objectives: The objective of the current study was to investigate the correlation of testicularvolume and semen parameter with varicocele grades in patients with varicocele attending theDepartment of Urology of Al-Jumhory Teaching Hospital.Materials and methods: The current study was a case-control study which was conducted inthe Department of Urology at Al-Jumhory Teaching hospital, Mosul city, Iraq, during the periodJanuary 2018 to June 2019. A total of 250 participants were enrolled in this study (200 patientswith clinical varicocele and 50 healthy volunteers). Seminal fluid analysis, testicular size measuredby ultrasound scanning, and varicocele grading according to standard criteria based on clinicalexamination and Doppler study of genitalia were performed for all participants. Statistical analysiswas applied to test the correlation of testicular size and seminal fluid parameter with varicocelegrade.Results: Patients with varicocele were classified into three groups based on the grade of varicocele:Group I included 22 patients with Grade I varicocele (12%), Group II included 82 patients withGrade II varicocele (38%), and Group III included 96 patients with Grade III varicocele (50%).Besides, Group IV was assigned to healthy volunteers (50) as a control group. Sperms with normalmotility and morphology were 33% and 32%, 25% and 25%, 10% and 15%, 60% and 65% in groupI, group II, group III, and group IV respectively. There were significant statistical differences(P-value<0.05) between the testicular volumes of both Group II and Grade III and control groups.Conclusion: Men with large varicocele had significantly abnormal semen parameters as well asdecreased ipsilateral testicular volumes compared to men with small varicocele or healthy men.
 A. Agarwal, R. Sharma, A. Harlev, and S. C. Esteves.
Effect of varicocele on semen characteristics according
to the new 2010 world health organization criteria:a
systematic review and meta-analysis.Asian J. Androl.,
Does varicocele grade predict the postoperative changes
varicocelectomy?Asian J. Urol., 2(3):163–166, 2015.
 W. H. Organization. The influence of varicocele on pa-
rameters of fertility in a large group of men presenting to
infertility clinics.Fertil. Steril., 57(6):1289–1293, 1992.
 W. F. Hendry, I. F. Sommerville, R. R. Hall, and R. C. B.
Pugh. Investigation and treatment of the subfertile male.
Br. J. Urol., 45(6):684–692, 1973.
 K. U. Rehmanet al.Correlation between testicular
hemodynamic and semen quality indices in clinical varic-
ocele patients in pakistan.Biomed Res. Int., 2019.
 C. K. Naughton, A. K. Nangia, and A. Agarwal. Varic-
ocele and male infertility:part ii:pathophysiology of
varicoceles in male infertility.Hum. Reprod. Update,
 D. A. Paduch and S. J. Skoog.Diagnosis, evaluation,
and treatment of adolescent varicocele.Scientific World
Journal, 4, 2004.
 S. M. H. Arraki. Evaluation of the effect of varicocelec-
tomy on semen parameters and fertility.Diyala J. Med.,
 A. Zini, M. Buckspan, D. Berardinucci, and K. Jarvi.
The influence of clinical and subclinical varicocele on tes-
ticular volume.Fertil. Steril., 68(4):671674, 1997.
 K. J. Pinto, R. Lawrence Kroovand, and J. P. Jarow.
Varicocele related testicular atrophy and its predictive
effect upon fertility.J. Urol., 152(2):788–790, 1994.
 S. M. Petak, H. R. Nankin, R. F. Spark, R. S. Swerdloff,
and L. J. Rodriguez-Rigau. American association of clin-
ical endocrinologists medical guidelines for clinical prac-
tice for the evaluation and treatment of hypogonadism
in adult male patients–2002 update.Endocr. Pract. Off.
J. Am. Coll. Endocrinol. Am. Assoc. Clin. Endocrinol,
 M. A. Witt and L. I. Lipshultz. Varicocele: a progressive
or static lesion?Urology, 42(5):541–543, 1993.
 E. W. Salzhauer, A. Sokol, and K. I. Glassberg.Pa-
ternity after adolescent varicocele repair.Pediatrics,
 E. J. Kass. The evaluation and management of the ado-
lescent with a varicocele.AUA Updat. Ser., 12:90–95,
 S. V Krishna Reddy, A. Basha Shaik, S. Sailaja, and
M. Venkataramanaiah. Outcome of varicocelectomy with
different degrees of clinical varicocele in infertile male.
Adv. Androl., 2015.
 A. Zini, M. Buckspan, D. Berardinucci, and K. Jarvi.
Loss of left testicular volume in men with clinical left
varicocele:correlation with grade of varicocele.Arch.
Androl., 41(1):37–41, 1998.
 A. Agarwal, S. Prabakaran, and S. C. Sikka.Current
opinions on varicocele and oxidative stress and its role in
male infertility.US Genitourin. Dis., page 6268, 2006.
 J. I. Sandlow. Do varicoceles really affect male fertility?
Sex. Reprod. Menopause, 2(4):219–221, 2004.
 J. C. Singh and N. Kekre.Does testicular hypotrophy
correlate with grade of adolescent varicocele?Indian J.
Urol., 21(2), 2005.
 E. J. Kass, B. R. Stork, and B. W. Steinert. Varicocele in
adolescence induces left and right testicular volume loss.
BJU Int., 87(6):499–501, 2001.
 M. H. Schlesinger, I. F. Wilets, and H. M. Nagler. Treat-
ment outcome after varicocelectomy. a critical analysis.
Urol. Clin. North Am., 21(3):517–529, 1994.
 M. Sigman and J. P. Jarow.Ipsilateral testicular hy-
potrophy is associated with decreased sperm counts in
infertile men with varicoceles.J. Urol., 158(2):605–607
 O. Steeno, J. Knops, L. Declerck, A. Adimoelja, and
H. Van de Voorde.Prevention of fertility disorders by
detection and treatment of varicocele at school and col-
lege age.Andrologia, 8(1):47–53, 1976.
Varicocelectomy.Pakistan journal of surgery, 22(3):139,
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