Document Type : Original articles


General Directorate of Education in Anbar, Gifted Guardianship Committee, Ministry of Education in Iraq, Anbar, Iraq.


Background: Food ingestion and energy spending are organized through a complicated neurological system that involves both hypothalamic centers and peripheral satiety regulation (gastrointestinal and pancreatic hormones).
Objectives: To assess the effects of sugar addiction on appetite-related hormones and metabolic hormones.
Material and Methods: The study was done in two main hospitals in Anbar governorate, Iraq from April 2020 to November 2020. Concentration of fasting blood glucose (FBG), insulin, hormone insulin resistance (HOMA-IR), leptin, ghrelin, lipid profile, TSH, T3, and T4 were measured in the 54 obese adolescents and were compared with 54 normal-weight adolescents.
Results: There was a significant increase in the concentrations of FBG, insulin, HOMA-IR, leptin, total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), and TSH in obese adolescents as compared to normal-weight adolescents (P-value < 0.05). While there was a significant (P < 0.05) decreased in the concentrations of ghrelin, high-density lipoprotein cholesterol (HDL-C), T3, and T4 in obese adolescents compared with normal-weight adolescents. The results also showed that there is a significant positive correlation between the concentration of leptin and each of BMI,  FBG, insulin, and HOMA-IR, while there was a significant negative association between leptin level with HDL-C and ghrelin.
Conclusion: Sweet-tasting meals are a major source of stimulation, which leads to overeating and thus leads to obesity. 


Main Subjects

[1]      TARRAGON, Ernesto; MORENO, Juan José. Polyphenols and taste 2 receptors. Physiological, pathophysiological, and pharmacological implications. Biochemical Pharmacology,178; 114086, 2020.
[2]      T. R. Ribeiro, N. F. Frediani Pirolla, and N. M. Nascimento-Júnior. Artificial and natural sweeteners: Chemical and biological properties, production processes, and potential harmful effects.Revista Virtual De Quimica, 1278-1318, 2020
[3]      S. Turner et al. Consuming gymnema sylvestre reduces the desire for high-sugar sweet foods. Nutrient,12(4); 1046, 2020.
[4]      N. Kashima, K. Kimura, N. Nishitani, M. Y. Endo, Y. Fukuba, and H. Kashima, Suppression of oral sweet sensations during consumption of sweet food in humans: Effects on gastric emptying rate, glycemic response, appetite, food satisfaction and desire for basic tastes. Nutrients, 12(5); 1249, 2020.
[5]      M. Anan et al. Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system. Heliyon, 6(5); e03947, 2020.
[6]      H. Edemann-Callesen, S. Barak, R. Hadar, and C. Winter. Choosing the Optimal Brain Target for Neuromodulation Therapies as Alcohol Addiction Progresses—Insights From Pre-Clinical Studies. Current Addiction Reports. 1-8, 2020.
[7]      M. Corkrum et al. Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity. Neuron. 105(6); 1036-1047, 2020.
[8]      Y. M. Arabi et al. Leptin, ghrelin, and leptin/ghrelin ratio in critically ill patients. Nutrients, 12(1); 36, 2020.
[9]      B. A. A. Saeed, H. A. Alsalkhi, S. E. Kasim, A. N. Rgeeb, and Q. M. Taher. Impact of leptin hormone on cardiac function in a sample of Iraqi population with cardiovascular disease. Int. J. Pharm. Res.,9(15);761, 2020.
[10]    A. Lindqvist et al. Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels. Mol. Cell. Endocrinol., 511; 110835, 2020.
[11]    World Health Organization (WHO). BMI Classification. WHO Global Database on Body Mass Index. 2014.‏
[12]    M. S. Hickey et al. Leptin is related to body fat content in male distance runners.  Am. J. Physiol. - Endocrinol. Metab., 271(5); E938-E940, 1996.
[13]    A. O. Bawajeeh, S. A. Albar, H. Zhang, M. A. Zulyniak, C. E. L. Evans, and J. E. Cade. Impact of taste on food choices in adolescence— systematic review and meta‐analysis. Nutrients.12(7); 1985, 2020.
[14]    B. Arcidiacono et al. Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance. EBioMedicine, 59; 102912, 2020.
[15]    D. C. Guzmán, H. J. Olguín, Q. V. Corona, M. O. Herrera, N. O. Brizuela, and G. B. Mejía. Consumption of cooked common beans or saponins could reduce the risk of diabetic complications. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13; 3481, 2020.
[16]    R. Nussbaumer et al. First-Phase Insulin and Amylin after Bariatric Surgery: A Prospective Randomized Trial on Patients with Insulin Resistance or Diabetes after Gastric Bypass or Sleeve Gastrectomy. Obes. Facts, 13(6); 584-595, 2020.
[17]    N. A. Emi et al. Associations of an empirical dietary pattern with cardiometabolic risk factors in Malaysian adolescents.  Nutr. Metab, 17(1); 1-10, 2020.
[18]    A. Sarı and M. B. Sadeq. THE RELATIONSHIP THE LEPTIN HORMONE, OBESITY AND DIABETES. E-journal New World Sci. Acad. 15(2); 40-48, 2020.
[19]    E. Tajiri, E. Yoshimura, Y. Hatamoto, H. Shiratsuchi, S. Tanaka, and S. Shimoda, Acute sleep curtailment increases sweet taste preference, appetite and food intake in healthy young adults: A randomized crossover trial.  Behavioral Sciences, 10(2); 47, 2020.
[20]    J. R. Dalenberg et al. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metab., 31(3); 493-502, 2020.
[21]    M. J. Redondo et al. Sex differences in circulating leptin as a marker of adiposity in obese or overweight adolescents with type 1 diabetes.  BMJ Open Diabetes Res. Care, 8(1); e001683, 2020.
[22]    P. Chrysafi et al. Leptin alters energy intake and fat mass but not energy expenditure in lean subjects.  Nat. Commun., 11(1); 1-15, 2020.
[23]    J. Hwang et al. The role of leptin in the association between obesity and psoriasis. Biomol. Ther., 29(1); 11, 2021.
[24]    C. Frithioff-Bøjsøe et al.Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. Pediatr. Diabetes, 21(2); 194-202, 2020.
[25]    M. Lonnie, L. Wadolowska, and E. Bandurska-Stankiewicz. Dietary-Lifestyle Patterns Associated with Adiposity and Metabolic Abnormalities in Adult Men under 40 Years Old: A Cross-Sectional Study (MeDiSH Project). Nutrients, 12(3); 751, 2020.
[26]    H. Ghazizadeh et al. Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population. J. Clin. Lab. Anal., 34(5); e23160, 2020.
[27]    M. A. Elamin, S. M. Youseif, and H. A. Mohammed. Ghrelin, resistin and insulin in obese diabetic women in wad-madani, sudan.  African Health Sciences, 20(1); 266-276, 2020.
[28]    F. Ozcelik, A. I. Dastan, H. H. Pence, and M. Z. Ciraci. Adaptive Contribution of Thyroid Hormones in Obesity. International Journal of Negative Results, 1(2); 1-11,  2019.
[29]    K. Beaulieu et al. Impact of meal timing and chronotype on food reward and appetite control in young adults.  Nutrients, 12(5); 1506, 2020.
[30]    G. S. Aly et al. Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: A case control study.  Journal of Pediatric Endocrinology and Metabolism33(2); 199-204, 2020.