We read carefully the article by Saeed et al.  entitled "Prevalence of Helicobacter pylori Infection in Cigarette and Nargileh Smoking Males in Erbil City, Iraq" which was published in volume 18, issue 2, 2022 of Al-Anbar Medical Journal. On using serology (IgG antibody test) Saeed et al.  found that Helicobacter pylori (H. pylori) prevalence in smokers and nonsmokers were 64.9% and 45.5%, respectively (P = 0.03). The young age group (25-34 years old) had the highest prevalence (54.1%; P = 0.05), and 89.2% of H. pylori-infected individuals had gastric complaints (P = 0.01). Nargileh smokers made up half of the H. pylori-positive participants. We, hereby, explore the limitations of the published article and provide insight into the value of serology to diagnose H. pylori infection.